. 2014 Jun 13;9(6):e99586. doi: 10.1371/journal.pone.0099586

Table 1. The prevalence and tumor multiplicity of lung tumor formation in female A/J mice.

Treatment	Mice numbers	Tumor bearing mice	Prevalence (%)	Tumor multiplicity
1. Control	5	1	20	0.1±0.02
2. NNL (L)	10	5	50	0.85±0.05^* ^, ^†
3. NNK (H)	10	10	100	3.5±0.1^* ^, ^† ^,‡
4. TCDD	10	2	20	0.25±0.05
5. NNK(L)+TCDD	10	9	90	2.2±0.2^* ^, ^† ^,‡

*Significantly higher (p<0.05) compared to Control groups.

^†

Significantly higher (p<0.05) compared to TCDD groups.

^‡

Significantly higher (p<0.05) compared to NNK(L) groups.

The incidence and multiplicity of lung tumor formation in female A/J mice treated with low-dose NNK [NNK(L)], high-dose NNK [NNK(H)], TCDD, and TCDD combined with NNK(L). Tumor incidence is provided as the number of animals with tumors divided by the total number of animals at risk (%). Tumor multiplicity is the average tumor number observed in tumor-bearing mice. The data for lung tumor multiplicity are given as the mean ± SEM. *significantly higher (p<0.05) than the control group; ^†significantly higher (p<0.05) than the TCDD group; ^‡significantly higher (p<0.05) than the NNK(L) group.