Table 4.
Multivariable linear regression for secondary outcomes*
| Variable name | Estimate | Standard error | P -value |
|---|---|---|---|
|
a. Multivariable linear regression for RRT-free days | |||
| Intercept |
−40.32510 |
33.71933 |
0.2323 |
| Mean daily calorie intake during ICU admission |
0.00189 |
0.00171 |
0.2695 |
| Median daily calorie intake during ICU admission |
−1.09792 |
2.61145 |
0.6744 |
| Positive mean fluid balance |
−4.09805 |
0.87492 |
<.0001 |
| Treatment |
−1.97170 |
0.85163 |
0.0210 |
| Time from ICU admission to randomization (in days) |
−0.01644 |
0.00469 |
0.0005 |
| SOFA liver (score) |
−1.63540 |
0.44579 |
0.0003 |
| APPT |
−0.05581 |
0.02105 |
0.0083 |
| pH |
8.45062 |
4.27094 |
0.0484 |
|
b. Multivariate linear regression of ICU-free days | |||
| Intercept |
−221.76773 |
281.51940 |
0.4313 |
| Mean daily calorie intake during ICU admission |
0.00468 |
0.00649 |
0.4714 |
| Median daily calorie intake during ICU admission |
2.89089 |
8.90361 |
0.7456 |
| Positive mean fluid balance |
−19.69578 |
3.36383 |
<.0001 |
| Positive ventilation: no = reference group |
−13.45268 |
5.58339 |
0.0165 |
| Patient's weight (Kg) |
0.45320 |
0.13896 |
0.0012 |
| Time from ICU admission to randomization (days) |
−0.03736 |
0.01756 |
0.0340 |
| Last creatinine concentration |
0.11279 |
0.04434 |
0.0114 |
|
c. Multivariate linear regression of hospital-free days | |||
| Intercept |
25.05875 |
258.60573 |
0.9229 |
| Mean daily calorie intake during ICU admission |
−0.00349 |
0.00601 |
0.5625 |
| Median daily calorie intake during ICU admission |
2.11260 |
8.32222 |
0.7997 |
| Positive mean fluid balance |
−16.17529 |
3.08521 |
<.0001 |
| Patient's weight (Kg) |
0.29499 |
0.12933 |
0.0231 |
| Last serum urea concentration |
−3.72244 |
1.85441 |
0.0454 |
| Last creatinine concentration |
0.09767 |
0.04131 |
0.0185 |
| Glucose (mmol/L) | 1.09456 | 0.50830 | 0.0319 |
*Only DCI related variable and significant variables reported. SOFA, sequential organ failure assessment; activated partial thromboplastin time.