Table 2.
Impact of organ dysfunction on ICU LOS and mortality
| Dysfunction | Definition | n (%) | LOS (days) a | P value b | Mortality (%) a | P value b |
|---|---|---|---|---|---|---|
| Cardiac |
Low cardiac output requiring dobutamine |
9 (32.1) |
34 ± 24 vs. 33 ± 21 |
0.87 |
44.4 vs. 10.5 |
0.064 |
| Hemodynamic |
Hypotension requiring norepinephrine |
22 (78.6) |
37 ± 23 vs. 19 ± 10 |
0.067 |
27.3 vs. 0.0 |
0.20 |
| Microcirculatory |
Serum lactate >4.4 mmol/l |
9 (32.1) |
34 ± 24 vs. 32 ± 22 |
0.85 |
44.4 vs. 10.5 |
0.064 |
| Hematologic |
Platelet count <100/nl |
11 (39.3) |
40 ± 24 vs. 28 ± 20 |
0.18 |
27.3 vs. 17.6 |
0.44 |
| Respiratory |
Respiratory insufficiency requiring ventilation >24 hours |
17 (60.7) |
41 ± 24 vs. 21 ± 10 |
0.009 |
35.3 vs. 0.0 |
0.033 |
| Renal injury |
Serum creatinine >212 μmol/l or twofold increase |
14 (50) |
40 ± 26 vs. 27 ± 15 |
0.121 |
28.6 vs. 14.3 |
0.32 |
| Failure |
Serum creatinine >318 μmol/l or threefold increase |
11 (39) |
46 ± 25 vs. 25 ± 14 |
0.021 |
36.4 vs. 11.8 |
0.14 |
| Hepatic |
Bilirubin ≥70 μmol/l |
6 (21.4) |
47 ± 31 vs. 29 ± 17 |
0.24 |
33.3 vs. 18.2 |
0.38 |
| |
INR >1.5 |
15 (53.6) |
40 ± 25 vs. 26 ± 14 |
0.09 |
26.7 vs. 15.4 |
0.40 |
| |
ICG-PDR ≤10.3%/minute |
10 (35.7) |
48 ± 21 vs. 25 ± 17 |
0.005 |
40.0 vs. 11.1 |
0.098 |
| LiMAx <100 μg/kg/hour | 11 (39.3) | 44 ± 19 vs. 26 ± 21 | 0.028 | 54.5 vs. 0.0 | 0.001 |
ICG-PDR, indocyanine green plasma disappearance rate; INR, International Normalised Ratio; LiMAx, maximal liver function capacity; LOS, length of stay after onset of sepsis. aPresence versus absence of organ failure. bIndependent t test. bFisher’s exact test.