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. 2013 Apr 10;17(2):R67. doi: 10.1186/cc12606

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Copyright © 2013 Gonnert et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effects of polymicrobial sepsis on biliary excretion of two xenobiotics (DY635, ICG). Kinetics of (A) DY635 and (C) ICG with respect to biliary excretion in sham-operated as opposed to septic rats over an observation period of 30 minutes after intravenous administration (14 pmol/g; n = 6 animals/group; 15 hours after induction of sepsis). Cumulative biliary excretion of (B) DY635 and (D) ICG, respectively. *P < 0.05 for sham versus sepsis (DY635: P ≤ 0.001; ICG: P = 0.013). In septic animals biliary recovery of the two dyes was significantly reduced. ICG, indocyanine green.