Table 1.
Assessment of disease severity and laboratory markers of sepsis-associated inflammation and organ injury and dysfunction
| sham | sepsis | ||
|---|---|---|---|
| Unit | mean ± SEM | mean ± SEM | |
| Activity score | 1 (active) to 5 (lethargic) | 1.0 ± 0.0 | 3.9 ± 0.2a |
| Peritoneal exudate | ml | 0 | 5.3 ± 0.5a |
| Fibrin generation | 0 (none) to 3 (massive) | 0 | 2.6 ± 0.2a |
| White cell count | × 103/μl | 5 ± 0.4 | 0.9 ± 0.1a |
| Platelets | × 103/μl | 504.4 ± 32.1 | 294.7 ± 53.1a |
| IL6 | pg/ml | 407 ± 88 | 6,013 ± 2426a |
| LDH | IU/l | 233.3 ± 25.7 | 695.4 ± 65.8a |
| Ammonia | μmol/l | 200.2 ± 21.4 | 278.4 ± 35.9 |
| AST | IU/l | 76.3 ± 11.7 | 202.3 ± 43.5a |
| Albumin | g/dL | 2.6 ± 0.1 | 1.5 ± 0.1a |
| Hematocrit | % | 40.2 ± 0.6 | 49.4 ± 1.2a |
aP < 0.05 compared to sham. AST, aspartate aminotransferase; IL6, interleukin-6; LDH, lactate dehydrogenase; SEM, standard error of the mean. N = 12 per group.