Table 2.
Multivariable analysis of early (seven-day) mortality
| Variable |
All patients (N = 822) |
ICH (N = 262) |
||||
|---|---|---|---|---|---|---|
| N | OR (95% CI) | P | N | OR (95% CI) | P | |
| Type of hemorrhage |
822 |
|
|
|
|
|
| “Other”* |
189 |
1.0 |
||||
| Gastrointestinal |
264 |
0.61 (0.22 to 1.70) |
NS |
|||
| Deep-muscle |
107 |
0.51 (0.14 to 1.93) |
NS |
|||
| ICH |
262 |
5.05 (1.97 to 12.94) |
<0.001 |
|||
| Age (years) |
822 |
|
|
262 |
|
|
| ≤65 years |
129 |
1.0 |
|
34 |
1.0 |
|
| 66 to 75 |
144 |
1.01 (0.35 to 2.93) |
NS |
47 |
2.32 (0.57 to 9.47) |
NS |
| 76 to 85 |
368 |
1.67 (0.68 to 4.10) |
NS |
122 |
2.71 (0.78 to 9.34) |
NS |
| >85 |
181 |
2.21 (0.84 to 5.77) |
NS |
59 |
3.79 (1.01 to 14.26) |
0.049 |
| Admission INR |
822 |
|
|
262 |
|
|
| ≤1.5 |
45 |
1.0 |
|
17 |
1.0 |
|
| No INR |
38 |
0.76 (0.12 to 4.71) |
NS |
13 |
1.01 (0.11 to 9.71) |
NS |
| >1.5 to 4 |
394 |
1.12 (0.33 to 3.80) |
NS |
162 |
1.40 (0.32 to 6.19) |
NS |
| >4 |
345 |
1.36 (0.38 to 4.87) |
NS |
70 |
1.56 (0.31 to 7.81) |
NS |
| GCS score |
813 |
|
|
261 |
|
|
| >13 |
684 |
1.0 |
|
149 |
1.0 |
|
| 9 to 13 |
65 |
3.67 (1.80 to 7.51) |
<0.001 |
51 |
4.23 (1.87 to 9.53) |
<.001 |
| ≤8 |
64 |
30.35 (13.43 to 68.61) |
<0.001 |
61 |
39.81 (15.70 to 100.91) |
<.001 |
| SAP |
819 |
|
|
262 |
|
|
| 90 to 140 mmHg |
411 |
1.0 |
|
64 |
1.0 |
|
| <90 mmHg |
74 |
7.91 (3.06 to 20.44) |
<0.001 |
3 |
0.67 (0.01 to 33.01) |
NS |
| >140 mmHg |
334 |
1.15 (0.58 to 2.28) |
NS |
195 |
1.29 (0.55 to 3.06) |
NS |
| VKA reversal |
822 |
|
|
262 |
|
|
| Guideline concordant |
313 |
1.0 |
0.011 |
116 |
1.0 |
.002 |
| Not guideline-concordant |
509 |
2.15 (1.20 to 3.88) |
|
146 |
3.23 (1.53 to 6.79) |
|
| Hosmer–Lemeshow Goodness-of-Fit Test: Pr >χ2 = 0.99 |
Hosmer–Lemeshow Goodness-of-Fit Test: Pr >χ2 = 0.52 |
|||||
| c-statistic = 0.89 | c-statistic = 0.86 | |||||
CI, confidence interval; ICH, intracranial hemorrhage; GCS, Glasgow coma scale; NS, not statistically significant; OR, odds ratio; SAP, systolic arterial blood pressure; trt: treatment.
*“Other” types include hemopericardium (N = 1), hemothorax (N = 15), vascular bound (N = 4), emergency procedures (N = 126) and shock or red blood cell transfusion for epistaxis (N = 55), hematuria (N = 34) or a wound of the scalp (N = 4).