Figure 4.

Profile of plasma neurofilament levels in patients with and without Intensive Care Unit-acquired weakness. Longitudinal neurofilament profiles, represented as changes compared to baseline levels, over a 10 day period following admission to ICU. Light gray lines represent individual patients; the black lines summarize group levels using local fit regression lines (with the 95% confidence curves in the grey shaded area). In patients without ICU-AW, neurofilament levels remained relatively stable on a group level (A), regardless of the presence of chronic neurological co-morbidities (C and E). In patients with ICU-AW there was a rise over time (B). ICU-AW patients without any chronic neurological co-morbidity had a more homogenous neurofilament profile (D) when compared to patients with any chronic neurological co-morbidity (F). Data are missing for seven patients because admission blood samples were not obtained or could not be analyzed successfully. ICU-AW, Intensive Care Unit–acquired weakness; NfH, neurofilaments.