Table 4. Genotype and allele distributions of polymorphisms of endothelial nitric oxide synthase (NOS3) gene in high-tension primary open-angle glaucoma patients and controls in Egyptians.

Parameters	Males				Females
	Cases; n=76	Controls; n=56	Odds ratio (95%CI)	P value*	Cases; n=84	Controls; n=54	Odds ratio (95%CI)	P value*
NOS3 T-786C (rs2070744)
TT	32 (42.1%)	30 (53.6%)	Reference	–	31 (36.9%)	30 (55.6%)	Reference	–
TC	26 (34.2%)	19 (33.9%)	1.01 (0.49–2.10)	0.97	33 (39.3%)	19 (35.2%)	1.19 (0.59–2.42)	0.63
CC	18 (23.7%)	7 (12.5%)	2.17 (0.84–5.63)	0.11	20 (23.8%)	5 (9.3%)	3.06 (1.07–8.74)	0.03
T allele	90 (59.2%)	79 (69.6%)	Reference	–	95 (57.6%)	79 (73.1%)	Reference	–
C allele	62 (40.8%)	33 (30.4%)	1.65 (0.98–2.77)	0.06	73 (43.5%)	29 (26.9%)	2.09 (1.24–3.53)	0.005
NOS3 Glu298Asp (rs1799983)
Glu/Glu	41 (53.9%)	32 (57.1%)	Reference	–	40 (46.6%)	31 (57.4%)	Reference	–
Glu/Asp	24 (31.6%)	19 (33.9%)	0.90 (0.43–1.87)	0.78	35 (41.7%)	18 (33.3%)	1.43 (0.70–2.91)	0.33
Asp/Asp	11 (14.5%)	5 (8.9%)	1.73 (0.56–5.28)	0.33	9 (10.7%)	5 (9.3%)	1.18 (0.37–3.72)	0.78
Glu allele	106 (69.7%)	83 (74.1%)	Reference	–	115 (68.5%)	80 (74.0%)	Reference	–
Asp allele	46 (30.3%)	29 (25.9%)	1.24 (0.72–2.14)	0.44	53 (31.6%)	28 (26.0%)	1.32 (0.77–2.26)	0.32
Intron 4 polymorphism of NOS3
b/b	53 (69.7%)	38 (67.9%)	Reference	–	57 (67.9%)	32 (59.3%)	Reference	–
b/a	18 (23.7%)	14 (25.0%)	0.93 (0.42–2.08)	0.86	23 (27.4%)	18 (33.3%)	0.75 (0.36–1.58)	0.46
a/a	5 (6.6%)	4 (7.1%)	0.92 (0.23–3.58)	0.90	4 (4.8%)	4 (7.4%)	0.63 (0.15–2.61)	0.52
b allele	124 (81.6%)	90 (80.3%)	Reference	–	137 (81.6%)	82 (75.9%)	Reference	–
a allele	28 (18.4%)	22 (19.6%)	0.92 (0.50–1.72)	0.80	31 (18.5%)	26 (24.1%)	0.71 (0.40–1.29)	0.26

*Two-tailed chi square (χ²) test significant at <0.05; CI: confidence interval