Table 3. Raloxifene metabolites in plasma stratified by UGT1A8 genotype.

Group	Metabolite	UGT1A8 (*1/*3)a	UGT1A8 (*1/*1)+(*1/*2)a	UGT1A8(*2/*2)a
60 mg raloxifene	ral-6-Gluc/raloxifene	13 (1)	31 ± 27 (36)	43 ± 21 (5)
	ral-4′-Gluc/raloxifene	42	94 ± 74	146 ± 62
	total ral-Gluc/raloxifine	55	125 ± 96	189 ± 77
30 mg raloxifeneb	ral-6-Gluc/raloxifene	10 ± 14 (2)	27 ± 24 (37)
	ral-4′-Gluc/raloxifene	18 ± 9	93 ± 97
	total ral-Gluc/raloxifine	27 ± 23	120 ± 120
Combined treatment groups	ral-6-Gluc/raloxifenec	11 ± 10 (3)	29 ± 26 (73)	43 ± 21 (5)
	ral-4′-Gluc/raloxifened	26 ± 15	93 ± 86	146 ± 62
	total ral-Gluc/raloxifenee	37 ± 23	123 ± 101	189 ± 77

^aValues are ng/ml. Numbers in parenthesis represent the number of subjects analyzed in each group.

^bThere were no subjects with the UGT1A8 (*2/*2) genotype in this group.

^cp_trend=0.020,

^dp_trend=0.003;

^ep_trend=0.005.