Figure 3. Thalamocortical synaptic plasticity is unmasked in mature animals by 2-hoton glutamate uncaging at a TC input of cortical neurons.
(a) Synaptic stimulation via the thalamic radiation fails to induce TC LTD in slices from mice matured beyond the critical period. (b) The same pattern of stimulation delivered to a single thalamic input of an LIII/IV pyramidal neuron by TGU produces LTD.