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. Author manuscript; available in PMC: 2014 Jun 13.
Published in final edited form as: Neuroscientist. 2013 Apr 4;19(5):465–478. doi: 10.1177/1073858413482983

Figure 5. Cortical dysinhibition is required for TC LTP in mature animals.

Figure 5

(a) The 40-Hz tetanization of the thalamic radiation alone is not sufficient to induce TC LTP in mature animals. (b) Tetanization of the thalamic radiation coincident with deactivation of inhibitory inputs to LIII/IV pyramidal neurons via administration of intracellular picrotoxin (iPTX) is sufficient to induce TC LTP. Abbreviations: EPSC, excitatory postsynaptic currents; IPSCs, inhibitory postsynaptic currents. Scale bars: 100 pA, 10 ms.