Figure 3.

Concomitant IPMN and ITPN sharing a common GNAS mutation. Patient 130fp presented two different neoplastic lesions, an intestinal-type IPMN and an ITPN coexisting in pancreatic head. The two phenotypically different lesions showed a common GNAS R201H mutation; the ITPN component presented a NRAS Q61L mutation; representative H&E images of the lesions are shown (original magnifications = ×20). On the right of each sample is a representation of the reads aligned to the reference genome, as provided by the Integrative Genomics Viewer software (IGV v 2.1, Broad Institute) for the hotspot mutations in the GNAS and NRAS genes.