Table 2.
Mutational profile of non-invasive and invasive components in three cases of IPMN with associated carcinoma
| Sample | Subtype | Lesion | GNAS | KRAS | TP53 | BRAF | STK11 | CDKN2A | PTEN |
|---|---|---|---|---|---|---|---|---|---|
| #128fpB | Intestinal | HG dysplasia | R201H (38%) | V14I (37%) | K601E (33%) | ||||
| #128fpA | Intestinal | Colloid carcinoma | R201H (27%) | V14I (32%) | K601E (28%) | ||||
| #129fpB | Intestinal | IG dysplasia | G12V (42%) | E199D (58%) | V115M (7%) P70L (9%) | ||||
| #129fpA | Intestinal | Colloid carcinoma | G12V (16%) | E199D (57%) | |||||
| #138fpA | Pancreaticobiliary | HG dysplasia | G12D (44%) | V272L (81%) | Q171* (74%) | ||||
| #138fpB | Pancreaticobiliary | Tubular carcinoma | G12D (23%) | V272L (31%) |
IG, intermediate grade; HG, high grade. Mutated alleles percentages are shown in parentheses.