Table 2. Meta-analysis of the H1/H2 tagging SNP rs1052553 data from the present study and rs1052553 data from Vilariño-Güell et al.
and García-Martín et al. Analysis was performed in METAL. Effective sample size is corrected for unequal numbers of cases and controls in METAL.
| Study | (White non-Hispanic) Clark et al. (rs1052553) | (White non-AJ) Clark et al. (rs1052553) | Vilariño-Güell et al. (rs1052553) | García-Martín et al. (rs1052553) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cases (N=249) (Count, freq.) |
Controls (N=237) (Count, freq.) |
P (OR, 95% CI) | Cases (N=157) (Count, freq.) |
Controls (N=196) (Count, freq.) |
P (OR, 95% CI) | Cases (N=339) (Count, freq.) |
Controls (N=406) (Count, freq.) |
P (OR, 95% CI) | Cases (N=200) (Count, freq.) |
Controls (N=291) (Count, freq.) |
P (OR, 95% CI) | |
| Genotype | ||||||||||||
| AA (H1/H1) | 140 (0.56) | 143 (0.60) | 0.16 | 88 (0.56) | 125 (0.64) | 0.13 | 221 (0.65) | 231 (0.57) | 0.07 | 104 (0.52) | 158 (0.54) | 0.52 |
| AG (H1/H2) | 91 (0.37) | 86 (0.36) | 58 (0.37) | 65 (0.33) | 100 (0.30) | 148 (0.36) | 75 (0.38) | 111 (0.38) | ||||
| GG (H2/H2) | 18 (0.07) | 8 (0.03) | 11 (0.07) | 6 (0.03) | 18 (0.05) | 27 (0.07) | 21 (0.11) | 22 (0.08) | ||||
| Allele | ||||||||||||
| A | 371 (0.74) | 372 (0.78) | 0.13 (0.80, 0.60–1.07) | 234 (0.75) | 315 (0.80) | 0.06 (0.71, 0.50–1.02) | 542 (0.80) | 610 (0.75) | 0.03 (1.32, 1.03–1.69) | 283 (0.71) | 427 (0.73) | 0.37 (0.88, 0.66–1.17) |
| G | 127 (0.26) | 102 (0.22) | 0.13 (1.25, 0.93–1.67) | 80 (0.25) | 77 (0.20) | 0.06 (1.41, 0.98–2.00) | 136 (0.20) | 202 (0.25) | 0.03 (0.76, 0.59–0.97) | 117 (0.29) | 155 (0.27) | 0.37 (1.13, 0.86–1.51) |