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. 2014 Jun 6;8:735–744. doi: 10.2147/DDDT.S60672

Figure 1.

Figure 1

Mechanism of EGFR-related lung cancer drug resistance.

Abbreviations: AKT, protein kinase B; EGFR, epidermal growth factor receptor; ERK, extracellular signal-regulated kinase; mTOR, mammalian target of rapamycin; PI3K, phosphatidylinositol 3-kinase; RAF, rapidly accelerated fibrosarcoma; RAS, rat sarcoma gene; EML4-ALK, echinoderm microtubule associated protein like 4 -anaplastic lymphoma kinase.