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. 2014 Jun 6;8:719–733. doi: 10.2147/DDDT.S58178

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© 2014 Paydar et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Effect of boldine on cytochrome c, membrane permeability, and MMP. (A) Representative images of boldine-treated and untreated MDA-MB-231 cells, stained with Hoechst 33342 for nuclear, cytochrome c, membrane permeability, MMP dyes. Boldine induced a noteworthy elevation in membrane permeability, cytochrome c release, and marked reduction in MMP (magnification, 200×). (B) Representative bar charts indicating mean fluorescence intensities of cell permeability, MMP, and cytochrome c release in control and boldine-treated MDA-MB-231 cells. *P<0.05 by Student’s t-test.

Abbreviation: MMP, mitochondrial membrane potential.