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Boldine activates intrinsic caspase-3/7 and caspase-9 activity. Relative luminescence expression of caspase-3/7, caspase-8, and caspase-9 in MDA-MB-231 cells treated with various concentrations of boldine (12.5, 25, 50 μg/mL) or 50 μg/mL boldine with 20 μM Z-VAD-FMK, a pan caspase inhibitor. *P<0.05 by Student’s t-test.
