Figure 7.

Boldine inhibits TNF-α-induced NF-κB nuclear translocation. (A) Photographs of intracellular targets of stained MDA-MB-231 cells, treated with boldine or curcumin (positive control) for 3 hours and then stimulated for 30 minutes with 1 ng/mL TNF-α (NF-κB activation). (B) Representative bar chart indicating that treatment with boldine partially blocked NF-κB translocation from the cytoplasm to the nucleus in TNF-α-stimulated MDA-MB-231 cells. Data were evaluated with the Student’s t-test (*P<0.05).

Abbreviations: NF-κB, nuclear factor kappa B; TNF-α, tumor necrosis factor alpha.