Table 1.
A
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Animal groups | Kidney function tests
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Sodium (mM/L) |
Potassium (mM/L) |
Chloride (mM/L) |
CO2 (mM/L) |
Anion (mM/L) |
Urea (mM/L) |
Creatinine (μM/L) |
|
Control | 139.74±2.07 | 5.37±0.37 | 101.45±2.11 | 22.59±0.18 | 18.97±0.28 | 5.17±0.13 | 45.37±2.01 |
50 mg/kg/day | 140.92±1.68 | 5.16±0.52 | 101.18±1.35 | 23.01±0.37 | 20.28±0.41 | 5.02±0.29 | 42.61 ±1.29 |
100 mg/kg/day | 137.58±2.21 | 5.24±0.19 | 99.76± 1.61 | 20.14±0.25 | 19.82±0.17 | 4.93±0.34 | 41.59± 1.72 |
B
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Animal groups | Liver function tests
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Total protein (g/L) | Albumin (g/L) | Globulin (g/L) | Total bilirubin μM/L) | Conjugated bilirubin (μM/L) | Alkaline phosphatase (IU/L) | Alanine transaminase (IU/L) | Aspartate transaminase (IU/L) | GGT (IU/L) | |
Control | 72.15± 1.28 | 12.62±0.24 | 58.42±1.04 | 2.21±0.130.9 | 0.94±0.23 | 136.12±3.18 | 52.71 ± 1.63 | 156.34±3.78 | 4.82±0.18 |
50 mg/kg/day | 71.38±1.54 | 12.17±0.32 | 57.91±0.83 | 2.09±0.08 | 0.87±0.17 | 137.25±1.54 | 52.49±2.44 | 154.91 ±3.24 | 4.26±0.25 |
100 mg/kg/day | 70.46± 1.03 | 12.35±0.18 | 59.13±1.17 | 1.98±0.11 | 0.91±0.14 | 136.01 ±2.78 | 53.27±2.06 | 155.48±1.96 | 4.73±0.22 |
C
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Animal groups | Hematological analysis
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HGB | HCT | RBC | MCV | MCH | MCHC | RDW | WBC | Platelet | |
Control | 157.24±3.14 | 0.64±0.01 | 8.73±0.35 | 64.71 ±1.89 | 18.23±0.37 | 307.56±4.81 | 17.43±0.94 | 8.61 ±1.14 | 862.94±27.45 |
50 mg/kg/day | 155.61 ±2.75 | 0.61 ±0.02 | 8.89±0.26 | 65.19±1.42 | 17.95±0.84 | 329.34±5.12 | 18.79±1.03 | 9.16±0.96 | 881.35±34.92 |
100 mg/kg/day | 154.94±2.88 | 0.63±0.01 | 9.01 ±0.31 | 65.82± 1.57 | 18.41 ±0.62 | 319.67±3.86 | 19.11±0.82 | 8.93± 1.05 | 913.58±29.65 |
Notes: (A) Values are expressed as the mean ± standard deviation. There are no significant differences between groups. (B) Values expressed as the mean ± standard deviation. There are no significant differences between groups. (C) Values are expressed as the mean ± standard deviation. There are no significant differences between groups.
Abbreviations: GGT, gamma glutamyl transferase; HGB, hemoglobin; HCT, hematocrit; RBC, red cell count; MCV, mean corpuscular volume; MCH, mean corpuscular hemoglobin; MCHC, mean corpuscular hemoglobin concentration; RDW, red cell distribution width; WBC, white blood cells; OECD, Organization for Economic Cooperation and Development.