Table 3.
Accuracy of blood and urinary concentrations of the different markers as indicators of different degrees of glomerular filtration rate impairment evaluated by means of receiver operating curves
| GFR < 90 ml/minute/1.73 m 2 | GFR <60 ml/minute/1.73 m 2 | GFR <45 ml/minute/1.73 m 2 | GFR <30 ml/minute/1.73 m 2 | GFR <15 ml/minute/1.73 m 2 | |
|---|---|---|---|---|---|
| Plasma NGAL (ng/ml) |
|
|
|
|
|
| AUC |
0.838***** |
0.845***** |
0.872***** |
0.912***** |
0.929***** |
| Criterion |
>102 |
>136 |
>213 |
>214 |
>270 |
| Sensitivity |
69.8 |
77.4 |
77.0 |
92.1 |
100 |
| Specificity |
87.5 |
82.0 |
84.3 |
76.1 |
75.5 |
| Plasma BNP (pg/ml) |
|
|
|
|
|
| AUC |
0.613** |
0.599** |
0.588* |
0.623** |
0.579 NS |
| Criterion |
>31.3 |
>51.9 |
>26.6 |
>26.6 |
>28.3 |
| Sensitivity |
34 |
25 |
48 |
54 |
50 |
| Specificity |
85 |
93 |
71 |
68 |
67 |
| Serum creatinine (mg/dl) |
|
|
|
|
|
| AUC |
0.895***** |
0.908***** |
0.943***** |
0.977***** |
0.990***** |
| Criterion |
>1.01 |
>1.25 |
>1.55 |
>2.14 |
>3.08 |
| Sensitivity |
82.9 |
81.0 |
85.6 |
90.2 |
100 |
| Specificity |
85.6 |
81.7 |
89.2 |
96.7 |
94 |
| Urinary NGAL (ng/ml) |
|
|
|
|
|
| AUC |
0.555 NS |
0.601** |
0.617*** |
0.635**** |
0.773*** |
| Criterion |
|
>8.2 |
>14.4 |
>20.2 |
>22.0 |
| Sensitivity |
|
49 |
42 |
47.6 |
70 |
| Specificity | 68 | 80 | 83 | 81 |
Values of the areas under the curve (AUC), criterion values, and sensitivity and specificity values are reported. The statistical significance of the different AUCs is indicated. *P < 0.05; **P < 0.01; ***P < 0.001;****P < 0.00001. BNP, B-type natriuretic peptide; GFR, glomerular filtration rate; NGAL, neutrophil gelatinase-associated lipocalin.