Table 2.
Pharmacokinetic parameters of amikacin loading dose according to the creatinine clearance (CrCl) at the onset of therapy
| Parameter | All patients (n = 63) | CrCl ≥50 mL/min (n = 46) | CrCl <50 mL/min (n = 17) |
|---|---|---|---|
| Vd (L) | 26.32 (8.4-51.7) | 25.7 (8.5-49.3) | 38.8 (8.4-46.7) |
| Vd (L/kg) | 0.42 (0.12-1.03) | 0.40 (0.12-1.03) | 0.66 (0.2-0.8)* |
| t1/2 (h) | 5.4 (0.8-19.9) | 4.9 (0.8-11.0) | 7.8 (3.2-19.1)* |
| CL (mL/min) | 3.3 (0.6-25.3) | 3.4 (1.5-25.8) | 3.3 (0.6-9.9) |
| AUC0-24 (mg*h/L) | 462 (58-1867) | 361 (58-1045) | 507 (153-1867) |
Data are presented as median (ranges). *P = 0.05 vs. CrCl ≥50 mL/min. Vd, volume of distribution; t1/2 , half-life; CL, drug clearance; AUC0-24, area under the curve for the first day of therapy.