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. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: Proteins. 2014 Jan 25;82(7):1387–1399. doi: 10.1002/prot.24506

Figure 2.

Figure 2

Describing the proton abstraction by the imidazole base as part of the stepwise mechanism. The resulting intermediate products are doubly protonated HIS, i.e.δ,ε-Histidine, and the alcoholate nucleophile.