Table 1.
Comparisons of clinical variables between cases and controls
| Variable | Cases (n) | Controls (n) | P |
|---|---|---|---|
| Age (years) |
68 +/- 16 (197) |
67 +/- 16 (197) |
0.935b |
| Male gender |
129 (197) |
129 (197) |
1.000a |
| LVEF (%) |
35 +/- 12 (197) |
60 +/- 5 (197) |
<0.001
b
|
| APACHE II |
20 +/- 7 (194) |
19 +/- 8 (191) |
0.603b |
| Initial CVP (cm H2O) |
9 +/- 8 (128) |
8 +/- 7 (120) |
0.334b |
| ScVO2 (%) |
67 +/- 17 (166) |
71 +/- 16 (166) |
0.009
b
|
| Lung Infection |
64 (197) |
54 (197) |
0.322a |
| Sepsis bundle compliant |
61 (197) |
69 (197) |
0.453a |
| MAP <65 mm Hg |
116 (197) |
114 (197) |
0.919a |
| Initial temperature (°C) |
36.9 +/- 1.6 (196) |
37.0 +/- 1.5 (195) |
0.714b |
| Temperature at 24 hours (°C) |
37.2 +/- 2.0 (197) |
37.3 +/- 2.0 (197) |
0.471b |
| Initial heart rate (min−1) |
104 +/- 27 (197) |
108 +/- 24 (197) |
0.074b |
| Heart rate at 24 hours (min−1) |
115 +/- 32 (197) |
117 +/- 29 (197) |
0.360b |
| Initial respiratory rate (min−1) |
24 +/- 9 (197) |
24 +/- 9 (197) |
0.558b |
| Respiratory rate at 24 hours (min−1) |
29 +/- 9 (197) |
30 +/- 9 (197) |
0.435b |
| Initial MAP (mm Hg) |
74 +/- 22 (197) |
76 +/- 23 (197) |
0.502b |
| MAP at 24 hours (mm Hg) |
58 +/- 19 (197) |
60 +/- 21 (197) |
0.226b |
| Initial pH |
7.35 +/- 0.12 (176) |
7.35 +/- 0.13 (175) |
0.994b |
| pH at 24 hours |
7.31 +/- 0.13 (112) |
7.29 +/- 0.15 (107) |
0.302b |
| Initial PO2/FiO2 |
259 +/- 130 (161) |
266 +/- 139 (166) |
0.630b |
| PO2/FiO2 at 24 hours |
265 +/- 113 (108) |
268 +/- 126 (115) |
0.846b |
| Initial sodium (mg/dL) |
139 +/- 7 (196) |
139 +/- 12 (197) |
0.730b |
| Initial creatinine (mg/dL) |
3.04 +/- 2.72 (195) |
2.73 +/- 3.28 (197) |
0.115c |
| Initial hematocrit (%) |
31.6 +/- 6.6 (197) |
33.1 +/- 8.1 (197) |
0.046
b
|
| Initial WBC (x103 ul) |
15.1 +/- 9.7 (196) |
16.4 +/- 15.6 (197) |
0.294b |
| Initial platelet count (x103 ul) |
234 +/- 138 (195) |
231 +/- 153 (196) |
0.844b |
| Initial lactate (mmol/L) |
3.4 +/- 3.0 (196) |
4.1 +/- 3.5 (195) |
0.019
c
|
| Initial glucose (mg/dL) |
136 +/- 98 (197) |
136 +/- 52 (197) |
0.960b |
| Initial 24-hour fluid volume (ml) |
4,005 +/- 2,763 (190) |
4,378 +/- 3,040 (192) |
0.321c |
| Receipt of vasoactive agents | 88 (197) | 79 (197) | 0.415a |
Significance, P <0.05; aChi-square test; bStudent’s t-test; cMann-Whitney U test. APACHE II, Acute Physiology and Chronic Health Evaluation II; CVP, central venous pressure; LVEF, left ventricular ejection fraction; MAP, mean arterial pressure; PO2/FiO2, partial pressure of oxygen to the fraction of inspired oxygen; ScVO2, mixed venous oxygen saturation; WBC, white blood count.