Skip to main content
. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: Addict Biol. 2013 Dec 13;20(2):275–284. doi: 10.1111/adb.12120

Figure 3.

Figure 3

CRF1R antagonism, but not functional adrenergic receptor antagonism, reverses heroin withdrawal-induced mechanical hypersensitivity during acute dependence. For all tests, heroin-treated rats (n = 7–8/group) showed significantly lower paw withdrawal thresholds compared to saline-treated rats (** p < 0.005). (A) MPZP treatment significantly raised thresholds, indicating an alleviation of mechanical hypersensitivity (+ p < 0.05). (B–D) Neither clonidine (10 μg/kg, 50 μg/kg, SC), prazosin (2mg/kg, IP), nor propranolol (10 mg/kg, IP) alleviated the acute heroin dependence-induced mechanical hypersensitivity.