Table 2.
Organ failures, ICU management, and outcome.
| Characteristic | 1997-2004 47 patients |
2005-2010 42 patients |
P |
|---|---|---|---|
| Scoring systems (IQR) | |||
| Child-Pugh score | 9 (7-11) | 10 (8.25-11) | 0.22 |
| MELD day 1 | 25 (17-33.8) | 26 (20.2-32.8) | 0.43 |
| SAPS II day 1 | 56 (38-70.5) | 59 (42-76) | 0.10 |
| SOFA day 1 | 14 (8.5-17.5) | 13 (9-15) | 0.18 |
| Biological findings at ICU admission (IQR) | |||
| Serum creatinine level, μmol/L | 140 (96-199) | 147 (105-235) | 0.93 |
| Serum bilirubin level, μmol/L | 48 (35-110) | 68 (44.2-140.5) | 0.23 |
| Arterial blood lactate level, mmol/L | 4.2 (2-6.5) | 4.3 (2.2-7.9) | 0.68 |
| Serum sodium, mmol/L | 134 (130.5-139) | 135.5 (129.2-139) | 0.74 |
| Serum protein level, g/L | 54 (44.5-61) | 59 (50-66.8) | 0.05 |
| Factor V, % | 42 (33-64) | 46 (33-60) | 0.70 |
| INR | 2 (1.5-2.8) | 2 (1.6-3.1) | 0.69 |
| White blood cells, 103/mm3 | 13.6 (6.2-19) | 10.7 (6.4-15.2) | 0.45 |
| C-reactive protein, mg/L | 101 (60-167) | 75 (34-127) | 0.24 |
| Mechanical ventilation | 45 (95.7) | 39 (93) | 0.34 |
| Tidal volume, mL/kg (IQR)a | 8.6 (7.3-9.9) | 7 (6.1-7.9) | <0.001 |
| Lowest Pao2/Fio2 ratio (IQR) | 101 (80-150) | 117 (86-206) | 0.17 |
| ARDS | 16 (34) | 14 (33.3) | 1 |
| Renal replacement therapy | 34 (72.3) | 22 (52.4) | 0.08 |
| Antimicrobial treatment | |||
| β-lactam | 45 (95.7) | 41 (97.6) | 1 |
| Quinolone | 19 (40.4) | 12 (25.5) | 0.27 |
| Aminoglycoside | 23 (49) | 22 (52.4) | 0.83 |
| Glycopeptide | 9 (19.1) | 6 (14.3) | 0.58 |
| Combination therapy | 31 (64) | 34 (81) | 0.15 |
| Inadequacy of initial antimicrobial treatment | 5 (10.6) | 3 (7.1) | 1 |
| Fluid loading within the first 3 days | |||
| Crystalloids, L (IQR) | 6 (3-8.9) | 3 (1.7-4.5) | <0.001 |
| Albumin resuscitation | 4 (8.5) | 24 (57.1) | <0.001 |
| Adjuvant therapies of sepsis | |||
| Intensive insulin therapy | 15 (31.9) | 35 (83.3) | <0.001 |
| Low-dose glucocorticoids | 21 (44.7) | 34 (81) | <0.001 |
| Activated protein C | 0 | 2 (4.8) | 1 |
| ICU survival | 8 (17) | 17 (40) | 0.02 |
| Hospital survival | 3 (6) | 12 (29) | 0.009 |
| 6-month survival | 3 (6) | 9 (21) | 0.06 |
Variables are expressed as number (percentage) or median (interquartile range (IQR)).
aThe predicted body weight was calculated using the following formulas: 50+0.91 (centimeters of height-152.4) (male patients) or 45.5+0.91(centimeters of height-152.4) (female patients).
ARDS, Acute Respiratory Distress Syndrome; INR, International Normalized Ratio; MELD, Model for End Stage Liver Disease; SAPS, Simplified Acute Physiology Score; SOFA, Sequential Organ Failure Assessment.