Table 6.
Predictors of hospital mortality by univariable and multivariable logistic regression analyses.
| Variablea | Univariable OR (95% CI) | P value | Multivariable adjusted OR (95% CI)b | P value |
|---|---|---|---|---|
| Demographics | ||||
| Age, per year | 1.02 (1.02-1.03) | <0.001 | 1.03 (1.02-1.04) | <0.001 |
| Source of admission | ||||
| Hospital floor versus ED | 1.90 (1.46-2.48) | <0.001 | 1.34 (0.97-1.85) | 0.80 |
| Other ICU versus ED | 1.38 (1.05-1.81) | 0.02 | 1.24 (0.64-2.38) | 0.53 |
| Time of ICU admission | ||||
| Per day from hospitalization | 1.06 (1.03-1.09) | <0.001 | 1.06 (1.03-1.09) | <0.001 |
| Comorbid conditions | ||||
| Chronic kidney disease | 1.51 (1.06-2.15) | 0.02 | 1.29 (0.80-2.08) | 0.29 |
| Hematological malignancy | 2.03 (1.01-4.09) | 0.048 | 1.40 (0.55-3.57) | 0.48 |
| Site of infection | ||||
| Lungs | 0.98 (0.75-1.27) | 0.85 | 2.04 (1.00-4.16) | 0.049 |
| Bones and joints | 5.94 (1.25-28.09) | 0.03 | 7.31 (1.05-50.77) | 0.04 |
| Infective endocarditis | 1.90 (0.70-5.13) | 0.21 | 5.43 (1.41-20.87) | 0.01 |
| Primary bacteremia | 4.46 (1.20-16.56) | 0.03 | 8.31 (1.55-44.49) | 0.01 |
| Microbiology and antimicrobials | ||||
| Culture-positive | 1.40 (1.08-1.82) | 0.01 | 0.88 (0.59-1.31) | 0.52 |
| Inappropriate antibiotics | 1.42 (1.17-1.71) | <0.001 | 0.86 (0.52-1.42) | 0.56 |
| Severity scores | ||||
| APS, per point | 1.07 (1.05-1.09) | 0.001 | 1.06 (1.03-1.09) | <0.001 |
| Organ failurec | ||||
| Renal | 1.36 (1.00-1.84) | 0.049 | 0.99 (0.64-1.55) | 0.98 |
| Respiratory | 1.31 (1.02-1.70) | 0.04 | 0.98 (0.70-1.36) | 0.90 |
| Cardiovascular | 1.71 (1.32-2.21) | <0.001 | 0.91 (0.57-1.44) | 0.68 |
| Central nervous system | 2.17 (1.67-2.82) | <0.001 | 1.15 (0.80-1.65) | 0.45 |
| Coagulation | 3.02 (1.95-4.68) | <0.001 | 2.59 (1.51-4.46) | 0.001 |
| Hepatic | 4.27 (2.28-7.98) | <0.001 | 6.30 (2.98-13.30) | <0.001 |
| Treatment on day 1 in the ICU | ||||
| Vasoactive agents | 2.07 (1.56-2.76) | <0.001 | 1.42 (0.88-2.30) | 0.15 |
| Mechanical ventilation | 3.17 (2.23-4.52) | <0.001 | 1.91 (1.21-3.02) | 0.005 |
aOnly variables that were significantly associated with hospital mortality on univariable or multivariable analyses are shown; bHosmer-Lemeshow test for goodness of fit for multivariable logistic regression model: χ2 = 7.208, degrees of freedom = 8, P = 0.51; corgan failure defined as Sequential Organ Failure Assessment (SOFA) score >2 for the specified organ. OR, odds ratio; CI, confidence interval; ED, emergency department; ICU, intensive care unit; APS, Acute Physiology Score, used in place of the Acute Physiology and Chronic Health Evaluation (APACHE) II score.