Table 2.
Bleeding characteristics and treatments administered to the 15 patients
| Parameter | Value | |
|---|---|---|
| Site of bleeding | ||
| Venoarterial ECMO | ||
| Mediastinal (post-surgery) | 11 (73.3) | |
| Venovenous ECMO | ||
| Mediastinal (post-surgery) | 1 | |
| Hemothorax | 1 | |
| Gynecologic | 1 | |
| Epistaxis | 1 | |
| Transfusion required | ||
| Packed red blood cell | 17 (13.5-19) | |
| Fresh-frozen plasma | 14 (9-21.5) | |
| Concentrated platelets | 5 (3-8) | |
| Biologic parameters before and after rFVIIa infusion | Before | After |
| Hemoglobin | 7.5 (7.1-8.6) | 9 (8.2-9.8) |
| Platelets | 83 (61-117) | 68 (61-106) |
| PT | 46 (42-52) | 101 (54-120) |
| aPTT | 1.7 (1.4-2.2) | 1.4 (1.2-1.9) |
| Ionized calcemia | 1.10 (1.05-1.20) | 1.17 (1.03-1.28) |
| pH | 7.37 (7.28-7.42) | 7.41 (7.34-7.47) |
| Temperature before rFVIIa infusion (°C) | 36.4 (34.3-37.1) | |
| rFVIIa dose infused (μg/kg) | 77 (54-144) | |
| Number of injections of rFVIIa, number of patients | ||
| 1 | 10 | |
| 2 | 3 | |
| 3 | 1 | |
| 4 | 1 | |
Data are expressed as number (%) or medians (IQR). aPTT, activated thromboplastin time; ECMO, extracorporeal membrane oxygenation; PT, prothrombin time; rFVIIA, recombinant factor VIIa.