Table 2.
Absolute values for miR expression (no unit) and protein abundance of MMPs and TIMPs (pg/ml) in plasma from patients with normal aortae and TAA patients with BAV or TAV.
| PLASMA ANALYTE | CONTROL | BAV | TAV |
|---|---|---|---|
| microRNA (2−ΔCt) | |||
| miR-1 (1X10−3) | 70.1±15.7 | 70.8±8.2 | 72.7±13.0 |
| miR-21 | 42.5±11.7 | 36.7±5.8 | 32.4±5.6 |
| miR-29a | 7.2±1.4 | 6.1±0.7 | 5.7±0.8 |
| miR-133a (1X10−3) | 45.0±12.7 | 114.5±22.9 | 128.0±30.0 |
| miR-143 (1X10−1) | 14.4±2.5 | 12.2±1.4 | 11.3±1.4 |
| miR-145 (1X10−2) | 94.3±11.4 | 69.8±5.0 | 84.3±11.0 |
| MMPs (pg/mL) | |||
| MMP-1 | ND | ND | ND |
| MMP-2 (1X104) | 53.4±4.7 | 45.6±3.6 | 41.9±3.1 |
| MMP-3 (1X103) | 22.8±3.6 | 16.1±2.9 | 19.7±4.6 |
| MMP-7 (1X102) | 20.8±18.4 | 16.0±6.3 | 35.5±14.5 |
| MMP-8 (1X102) | 91.0±28.9 | 13.3±3.5* | 10.8±1.3* |
| MMP-9 (1X104) | 83.6±21.5 | 25.6±3.5* | 41.8±5.3*# |
| MMP-12 | ND | ND | ND |
| MMP-13 (1X102) | 24.9±15.0 | 11.0±3.6 | 8.5±3.6 |
| TIMPs (pg/mL) | |||
| TIMP-1 (1X103) | 116.4±24.7 | 56.0±3.2* | 63.8±7.2* |
| TIMP-2 (1X103) | 55.2±2.8 | 43.6±1.7* | 46.9±2.4 |
| TIMP-3 (1X102) | 34.2±4.6 | 24.1±2.8 | 36.2±4.6 |
| TIMP-4 (1X102) | 19.4±2.9 | 14.7±1.2 | 13.3±1.1 |
|
| |||
| Sample Size (n) | 10 | 21 | 21 |