Table 3.
Cox regression analysis for 28-day mortality.
| Unadjusted | Adjusted | |||||
|---|---|---|---|---|---|---|
| Model 1 | Model 2 | |||||
| HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | |
| Mean fluid balance (L/day) | 1.99 (1.68 to 2.36) | <0.001 | 1.67 (1.33 to 2.09) | <0.001 | 1.33 (1.002 to 1.77) | 0.0048 |
| Mean urine volume (L/day) | 0.38 (0.29 to 0.51) | <0.001 | 0.47 (0.33 to 0.67) | <0.001 | 0.33 (0.21 to 0.52) | <0.001 |
| Diuretic use | 0.40 (0.23 to 0.70) | 0.001 | 0.25 (0.12 to 0.52) | <0.001 | 0.26 (0.13 to 0.53) | <0.001 |
| Diabetes | 1.16 (0.68 to 1.98) | 0.58 | 2.16 (1.09 to 4.26) | 0.027 | 2.08 (1.06 to 4.08) | 0.033 |
| Hypertension | 1.76 (1.06 to 2.94) | 0.03 | 2.18 (1.12 to 4.22) | 0.021 | 2.17 (1.12 to 4.24) | 0.023 |
| MFB*MUV | - | - | - | - | 1.53 (1.16-2.01) | 0.003 |
Variables considered for model 1 included age, gender, co-morbid diseases (diabetes, hypertension and cardiovascular disease), non-renal SOFA, sepsis, mean fluid balance, mean urine volume and diuretic use. In model 2, MFB*MUV (interaction term between MFB and MUV) was also included. Only significant variables are shown in the table. HR, hazard ratio; MFB, mean fluid balance; MUV, mean urine volume.