Table 4.

Sensitivity analysis considering presence of AKI according to RIFLE classification.

	Unadjusted		Adjusted
	HR (95% CI)	P	HR (95% CI)	P
Mean fluid balance/24hours (L)	1.74 (1.56 to 1.95)	<0.001	1.51 (1.31 to 1.74)	<0.001
Mean urine volume/24hours (L)	0.39 (0.32 to 0.48)	<0.001	0.48 (0.38 to 0.62)	<0.001
Diuretic use	0.34 (0.22 to 0.52)	<0.001	0.31 (0.19 to 0.51)	<0.001
Diabetes	1.36 (0.88 to 2.10)	0.17	1.75 (1.08 to 2.85)	0.023

Variables considered for the model included age, gender, co-morbid diseases (diabetes, hypertension and cardiovascular disease), non-renal SOFA, sepsis, mean fluid balance, mean urine volume and diuretic use. Only significant variables are shown in the table. AKI, acute kidney injury; HR, hazard ratio; RIFLE, Risk of renal dysfunction, Injury to the kidney, Failure of kidney function, Loss of kidney function and End-stage kidney disease.