Figure 4.

EV71 infection enhances secretions of proinflammatory cytokines in iDCs. Control: Uninfected iDCs; EV71 infection: EV71-infected iDCs; SP600125 or SB203580: iDCs preincubated with inhibitor SP600125 or SB203580. The cytokine levels of uninfected iDCs and EV71-infected iDCs with or without inhibitor SP600125 and SB203580 (20 μM) in the culture supernatants were harvested at 24 h p.i. were measured by luminex fluorescence technique. The data were expressed as mean ± SE from at least three independent experiments and analyzed by one-way ANOVA with Bonferroni post-hoctests (*p < 0.05, **P < 0.01 and ***P < 0.001).