Table 1.
Differential mRNA expressions of molecules in JNK1/2 and p38 MAPK signaling pathways in EV71-infected iDCs at different time points
| Gene symbol |
EV71/control (Fold changes) |
|||
|---|---|---|---|---|
| 1/2 h | 2 h | 8 h | 24 h | |
| MAP2K3 (MEK3) |
+1.58 |
+3.08 |
+1.13 |
+1.05 |
| MAP2K4 (MEK4) |
+1.25 |
+1.16 |
+2.05 |
-1.11 |
| MAP2K6 (MEK6) |
-1.08 |
+2.30 |
+1.76 |
+1.08 |
| MAP2K7 (MEK7) |
+1.61 |
+1.10 |
+2.75 |
+1.00 |
| MAPK8 (JNK1; SAPK1) |
+1.27 |
+2.30 |
+1.10 |
+1.40 |
| MAPK9 (JNK2; SAPK) |
+1.14 |
+1.31 |
+2.59 |
+1.18 |
| MAPK10 (JNK3) |
+1.89 |
+1.94 |
+2.51 |
-1.80 |
| MAPK11 (p38-β MAPK) |
+1.10 |
+2.81 |
+1.72 |
+1.01 |
| MAPK12 (p38–γ MAPK) |
+1.28 |
+1.06 |
+1.76 |
+1.25 |
| MAPK13 (p38 -δ MAPK) |
+1.39 |
-1.54 |
-1.15 |
-1.01 |
| MAPK14 (p38-α MAPK) |
+1.36 |
+1.30 |
+2.02 |
+1.19 |
| c-Jun |
+1.28 |
+1.89 |
+3.03 |
+3.30 |
| c-Fos |
+9.17 |
+8.12 |
+4.05 |
+3.32 |
| IFN-α1 |
-1.04 |
+1.79 |
+1.24 |
-2.15 |
| IFN-β |
-1.10 |
+2.24 |
+1.68 |
-2.02 |
| IL-2 |
-1.09 |
+4.32 |
+1.40 |
-4.88 |
| IL-6 |
-1.27 |
+2.83 |
-1.73 |
-1.25 |
| IL-10 |
-1.06 |
+1.91 |
+1.14 |
+1.18 |
| IL-12 |
+1.01 |
+1.22 |
+2.67 |
+1.49 |
| TNF-α | +1.59 | +2.44 | +1.45 | +1.74 |
Upregulated and downregulated transcripts are indicated as ‘+’ and ‘–’ values, respectively. The changes of mRNA expressions (≥2 or ≤-2 – fold) are indicated by boldface letters.