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. 2014 Jun 7;14:411. doi: 10.1186/1471-2407-14-411

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Copyright © 2014 Tachezy et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Trial flow. Patients are allocated either to intervention or control group after randomization. Patients in the intervention group undergo sequential neoadjuvant CRT (yellow bars) followed by curative surgery. Patients in the control group are subjected to upfront surgery. After completion of the study, subset analysis is performed stratifying patients with resectable vs. borderline resectable lesions. Both groups will receive adjuvant chemotherapy. No postoperative, adjuvant EBRT in patients undergoing upfront surgery (group 2) is performed.