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. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: Nanomedicine (Lond). 2014 Jan;9(1):121–134. doi: 10.2217/nnm.13.191

Figure 4. Effect of shape on nanoparticle binding avidity.

Figure 4

Shape, ligand length, and polymer flexibility all play a role in the active fractional area of a nano-carrier (AFAC). For a sphere, the AFAC is defined as (L-dB)/Dc, where L is the length of the ligand, db is the binding distance between the nanoparticle and the receptor, and Dc is the diameter of the nano-carrier. For particles with equal surface area, the ligand length, binding distance, and shape affects AFAC.