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. Author manuscript; available in PMC: 2014 Jun 14.
Published in final edited form as: J Immunol. 2013 Oct 7;191(10):5124–5138. doi: 10.4049/jimmunol.1301415

FIGURE 4.

FIGURE 4

Frequent and strong IFN-γ–producing CD8+ T cells preferentially induced by gB342–350 and gB561–569 epitopes in asymptomatic individuals. (A) PBMC-derived CD8+ T cells, either from 10 ASYMP or from 10 SYMP individuals, were stimulated with individual gB peptides. The number of gB epitope-specific, IFN-γ–producing T cells was determined by ELISPOT assay, as in Fig. 4. (B) Representative data from one SYMP and one ASYMP individual showing the number of gB epitope-specific CD8+ T cells per 100,000 cells detected ex vivo using several concentrations of tetramer. (C) The average number of gB epitope-specific, PBMC-derived CD8+ T cells per 100,000 cells from five HLA-A*02:01–positive, HSV-1–seropositive SYMP individuals versus five ASYMP individuals. The results are representative of two independent experiments. *p < 0.005, comparing ASYMP to SYMP individuals using one-way ANOVA test.