Figure 2.

Association between sex and treatment, and clinical outcome. *Tic = ticagrelor (n = 9333). ^†Clop = clopidogrel (n = 9291). ^‡Adjustment variables selected from the following: age, weight, waist circumference, smoking status, diabetes, hypertension, heart rate, systolic blood pressure, changes in electrocardiogram at entry, killip class at entry, haemoglobin, white blood cells, dyslipidaemia, angina pectoris, prior myocardial infarction, congestive heart failure, prior GI bleeding, prior percutaneous coronary intervention, prior coronary artery bypass grafting, prior transient ischaemic attack, non-haemorrhagic stroke, peripheral arterial disease, chronic renal disease, chronic obstructive pulmonary disease, final diagnosis, onset of symptoms to randomized treatment, GP Iib/IIIa inhibitors at randomization, randomized treatment, treatment approach, and region. ^§PLATO-defined and adjudicated¹⁹. ^††Any bleeding includes major, minor, and minimal bleedings. CABG, coronary artery bypass grafting; CI, confidence interval; COPD, chronic obstructive pulmonary disease; CV death, death from cardiovascular causes; ECG, electrocardiogram; GI, gastrointestinal bleeding; HR, hazard ratio; KM, Kaplan–Meier analysis; MI, myocardial infarction; PCI, percutaneous coronary intervention; TIA, transient ischaemic stroke.