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. 2009 Oct 30;87(2):323–332. doi: 10.1189/jlb.0809563

Figure 7.

Figure 7

LTB4 modulates CCL2 production. (A) Effect of LTB4 i.pl. injection (0.5 μg/cavity) on CCL2 production. (B) Effect of CP105,696 pretreatment (4 mg/kg, i.p.) on LPS (250 ng/cavity, i.pl.)-induced CCL2 synthesis. CCL2 protein levels were determined by ELISA in C57BL/6 mouse pleural fluids recovered 6 h after stimulation. Results are expressed as the mean ± sem from at least six animals/group from three different experiments. (C) Effect of LTB4 i.pl. injection (0.5 μg/cavity) on γδ T lymphocyte migration in WT or CCR2 KO mice within 24 h. *, Statistically significant differences (P≤0.05) between nonstimulated and stimulated animals; +, significant differences between stimulated and treated groups or between WT and KO animals. Data represent the mean ± sem from at least six animals.