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Approved drugs for oral HBV treatment.
| Characteristics | Lamivudine | Tenofovir | Adefovir | Entecavir | Telbivudine |
|---|---|---|---|---|---|
| year of approval | 1999 | 2001 | 2002 | 2006 | 2007 |
| resistance after five years | ca. 70% | not found yet | ca. 30% | ca. 1% | ca. 22% |
| medical assessment | well tolerated, main concern: resistance | less nephrotoxic than adefovir | nephrotoxic, less prone to resistance than lamivudine | well tolerated, more potent than lamivudine and adefovir | well tolerated, high potency, resistances appear after one year |
