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A simplified scheme demonstrating mediation of selective autophagy by ATG8. (A) A phagophore is decorated with ATG8 proteins (illustrated as a green drop); (B) ATG8 recognizes and binds the cargo receptor (pink L-shape) that is located on the surface of the cargo, resulting in its anchoring to the expanding phagophore; and (C) The full enclosure of the double membranes generates an autophagosome that contains the cargo and is decorated with ATG8 proteins.
