Table 1.

Developmental changes (fetal–28 weeks) in body and liver weights, hepatic copper and iron, and SAM and SAH concentrations. Values are expressed as mean ± SD.

Analysis	Fetal		3 weeks		12 weeks		20 weeks		28 weeks
	Control (n = 8)	Tx-j (n = 5)	Control (n = 11)	Tx-j (n = 10)	Control (n = 8)	Tx-j (n = 7)	Control (n = 9)	Tx-j (n = 6)	Control (n = 7)	Tx-j (n = 7)
Body weight (g)	ND	ND	9.29 ± 1.03	7.91 ± 0.84 *	32.3 ± 2.42	27.1 ± 1.45 *	34.8 ± 2.14	28.3 ± 1.10 *	38.7 ± 4.31	32.2 ± 2.58 *
Liver weight (g)	ND	ND	0.40 ± 0.060	0.35 ± 0.045 *	1.65 ± 0.12	1.40 ± 0.068 *	1.74 ± 0.14	1.72 ± 0.089	1.84 ± 0.27	1.68 ± 0.27
Liver/body ratio	ND	ND	0.043 ± 0.0035	0.044 ± 0.0024	0.051 ± 0.0017	0.052 ± 0.0024	0.050 ± 0.0026	0.061 ± 0.0030 *	0.047 ± 0.0021	0.052 ± 0.0045 *
Copper (μg/g) **	7.83 ± 0.72	1.49 ± 0.48 *	12.17 ± 1.72	30.65 ± 7.73 *	5.17 ± 0.99	223.16 ± 52.8 *	7.44 ± 1.84	351 ± 40.5 *	3.86 ± 0.19	190 ± 23.4 *,•
Iron (μg/g) **	53.34 ± 7.73	48.94 ± 6.08	23.54 ± 3.39	26.16 ± 5.68	68.76 ± 11.54	79.52 ± 35.84	84.60 ± 13.27	91.66 ± 3.42	97.58 ± 14.92	124.07 ± 7.89 *,•
SAM (nmol/g)	105.19 ± 24.83	82.13 ± 14.52	86.97 ± 17.82	122.55 ± 50.37 *	84.9 ± 11.9	76.6 ± 26.3	82.7 ± 17.2	99.9 ± 10.6	74.4 ± 13.2	77.2 ± 7.91
SAH (nmol/g)	4.04 ± 1.21	4.67 ± 2.88	25.94 ± 8.86	36.55 ± 13.35 *	42.5 ± 10.4	57.2 ± 15.7 *	56.6 ± 26.3	67.7 ± 13.4	28.2 ± 16.8	34.5 ± 11.4
SAM/SAH ratio	27.59 ± 10.16	23.17 ± 12.77	3.89 ± 1.84	3.39 ± 0.89	2.14 ± 0.69	1.41 ± 0.59 *	1.82 ± 1.13	1.51 ± 0.26	3.76 ± 1.33	2.12 ± 0.52

Values with * are significantly different (p < 0.05) between tx-j vs. control at each time point; ** Copper and iron concentrations at the three weeks time points are from livers of 8 controls and 5 tx-j mice; Values with • are significantly different (p < 0.05) within the same genotype between 20 and 28 weeks. ND = not determined. Fetal and three weeks data were previously published [19].