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Tumor cell survival after treatment of H3 melanoma brain metastasis cells. CDI, coefficient of drug interaction.
| Concentration (M) | Temsirolimus (% Survival) | Vemurafenib (% Survival) | Combined (% Survival) | CDI |
|---|---|---|---|---|
| 0 | 100 ± 4.7 | 100 ± 4.7 | 100 ± 4.7 | - |
| 0.05 | 87.6 ± 2.3 | 99.9 ± 6.5 | 85.6 ± 2.5 | 0.98 |
| 5 | 79.0 ± 3.4 | 64.0 ± 2.5 | 75.6 ± 4.3 | 1.50 |
| 10 | 79.8 ± 5.9 | 42.3 ± 1.2 | 46.8 ± 3.9 | 1.39 |
