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. 2014 May 21;15(5):9067–9081. doi: 10.3390/ijms15059067

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© 2014 by the authors; licensee MDPI, Basel, Switzerland

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Scheme 1. — Schematic illustration of pH-targeting gene delivery towards tumor cells with 4-arm PEG-SSPHIS copolymer as a pH and redox dual responsive gene delivery vector: (a) gene binding of 4-arm PEG-SSPHIS copolymer to form the polyplexes with almost neutral surface; (b) increased surface charge upon the polyplexes in acidic tumor microenvironment via protonation of imidazole groups; (c) enhanced cellular uptake of the polyplexes to tumor cells; (d) intracellular gene release after disulfide cleavage.