Table 2.
Serum levels of triglyceride, free fatty acid, total cholesterol, glucose and insulin of mice at week 30.
| Group | Treatment (number of mice examined) | Triglyceride (mg/dL) | Free fatty acid (mEq/L) | Total cholesterol (mg/dL) | Glucose (mg/dL) | Insulin (ng/dL) | IGF-1 (ng/dL) |
|---|---|---|---|---|---|---|---|
| 1 | 4-NQO (5) | 153.6 ± 43.2 a | 2235.6 ± 542.5 | 266.0 ± 48.2 | 128.4 ± 9.1 | 7.89 ± 2.71 | 547.4 ± 58.4 |
| 2 | 4-NQO—0.01% fenofibrate (5) | 161.2 ± 17.0 | 1540.8 ± 365.5 b | 250.0 ± 25.0 | 130.2 ± 24.4 | 1.31 ± 0.83 c | 456.3 ± 15.7 c |
| 3 | 4-NQO—0.05% fenofibrate (5) | 60.8 ± 19.0 c,d | 1154.4 ± 80.0 c | 201.8 ± 27.4 | 131.0 ± 11.7 | 0.16 ± 0.05 c | 367.1 ± 16.0 c |
| 4 | 0.05% fenofibrate (5) | 119.8 ± 28.0 e | 1218.4 ± 148.1 f | 217.4 ± 48.3 | 109.0 ± 14.7 | 0.05 ± 0.04 e | 317.7 ± 47.8 e |
| 5 | Non-treatment (5) | 208.2 ± 44.7 | 1876.8 ± 267.7 | 238.0 ± 60.4 | 113.6 ± 16.2 | 10.09 ± 1.07 | 573.8 ± 23.6 |
a
, Mean ± SD;
b
, Significantly different from group 1 (p < 0.05);
c
, Significantly different from group 1 (p < 0.01);
d
, Significantly different from group 2 (p < 0.01);
e
, Significantly different from group 5 (p < 0.01);
f
, Significantly different from group 5 (p < 0.05).