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. 2014 Jun 10;14:46. doi: 10.1186/1472-6823-14-46

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Copyright © 2014 Mamtani et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Development and validation of thyroid function index (TFI) as a marker of thyroid function. Results are color coded as blue for SAFHS and red for NHANES 2007–10 participants. (A) Spectrum of clinical thyroid status. Bars represent prevalence (%) while error bars represent 95% confidence interval. CO, clinical hypothyroidism; SO, subclinical hypothyroidism; EU, euthyroid; SR, subclinical hyperthyroidism; CR, clinical hyperthyroidism. (B) Effect of log-transformation on distribution of TFI. Left and right panels show histograms for raw and log-transformed TFI, respectively. (C) Box and whisker plots showing distribution of log-normalized TFI by thyroid status. (D) Receiver operating characteristics (ROC) curves comparing the discriminatory performance of TFI, TSH, FT3 and FT4 to detect clinical hypothyroidism. AUC, area under the ROC curve; CI, confidence interval.