Table 3.
Treatment of Alveolar Hemorrhage
| Therapy | rFVIIa (N = 43 episodes, 23 patients) | Conventional Therapy (N = 14 episodes, 14 patients) | P-value |
|---|---|---|---|
| Corticosteroidsa, median (IQR) | |||
| Total dose per episode (mg/kg) | 14.6 (4.8-37.6) | 12.6 (5.0-31.9) | 0.42 |
| Daily mean dose per episode (mg/kg/d) | 1.8 (0.8-3.6) | 2.1 (1.4-2.5) | 0.68 |
| Highest daily dose per episode (mg/kg/d) | 2.8 (1.2-7.9) | 2.2 (2.0-9.6) | 0.97 |
| rFVIIa, median (IQR) | |||
| Dose per administration (μg/kg) | 41 (39-62) | --- | |
| Doses per episode, n, median (IQR; range) | 3 (2-17; 1-57) | --- | |
| Cumulative dose (mg) per episode | 16 (4.8-37.6) | --- | |
| Additional hemostatic agents used, n (%) | 0.43 | ||
| Desmopressin acetate | 8 (18.6) | 1 (7.1) | |
| Aminocaproic acid | 2 (4.7) | 1 (7.1) | |
| Conjugated estrogens | 1 (2.3) | 0 |
Abbreviations: IQR indicates interquartile range; mg, milligrams; kg, kilogram; d, day; μg, microgram.
a
Expressed in methylprednisolone equivalents.