Table 4.
Post Mortem Histopathology Following Alveolar Hemorrhage
| rFVIIa (n = 7) | Conventional Therapy (n = 5) | |
|---|---|---|
| Time (days) of autopsy relative to last dose of therapy for AH (median, IQR) | 3 (2-3) | 20 (7-26) |
| Death due to respiratory failure, n (%) | 2 (29) | 1 (20) |
| Histopathologic Findings (n) | ||
| Dilated airspaces with intraalveolar hemorrhage in different stages of organization with partial clot formation, fibrin accumulation | 7 | 5 |
| Type II pneumocyte hyperplasia | 7 | 5 |
| Hemosiderin laden-macrophages (alveoli and interstitium)a | 6 | 5 |
| Focal hyaline membranes lining alveolar spaces | 6 | 1 |
| Organizing pneumonia with inflammation | 5 | 3 |
| Angioinvasive fungal infection | 2 | 1 |
| Underlying hematologic malignancy | 1b | 2c |
| Thromboemboli | 0 | 0 |
Abbreviations: IQR indicates interquartile range.
a
One patient without hemosiderin laden macrophages died 1 day after recurrence of alveolar hemorrhage
b
Gray zone lymphoma
c
Epstein–Barr virus associated lymphoproliferative disorder and nodular sclerosing Hodgkin’s lymphoma