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. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: J Invest Dermatol. 2014 Jan 17;134(7):1828–1838. doi: 10.1038/jid.2014.28

Table 1.

Results of enrichment tests for the modules containing the highest proportions of signature genes in keratinocytes/epidermis. For the cytokine-induced experiments, the dosage (ng/ml) and treatment time are included in the brackets.

Enrichment test‡
Gene signatures in cytokine-induced
experiments
Condition Module
Label		 Hub genes# Functions Transcription
Factor		 up down
Normal 10 TMEM54; PKP3;
LYPD3; ST14;
LAD1 		EDC; keratinization;
3' UTR-mediated
translational regulation
15 C1orf68;
LY6G6C; LCE1B;
NIPAL4;
SLC46A2 		keratinization IL17A (200ng|24hr) IL1a (10ng|24hr);
IL36g (5Kng|24hr);
IL22 (20ng|4d)
psoriatic 20 SERPINB4;
SERPINB3;
SLC6A14; TGFA;
HEPHL1 		inflammatory response;
immune response;
extracellular space		 STAT1; STAT3;
IRF3 		IL17A (200ng|24hr);
IL1a (10ng|24hr);
IL1a (25ng|48hr)
23 LCE1C; LCE2B;
LCE2C; LCE2D;
C1orf68 		EDC; keratinization HR IL36g (5Kng|24hr);
IL36RA (5Kng|24hr);
IL36b (5Kng|24hr)
26 CNFN; TREX2;
SPRR2B;
SPRR2D;
SULT2B1 		keratinization; EDC;
cornified envelope		 GLIS1 IL17A+TNF (10ng|24hr);
IL17A+TNF (1ng|24hr);
TNF (1ng|24hr)		 IL13 (20ng|24hr)
‡

Only the top 3 most significant results are shown.

#

Hub genes were defined as the genes having the highest similarity in the module, as assessed by the strength of correlation and the degree of shared neighbors based on the gene expression data, with other genes in the same module.