Table III.
Omnibus tests and post-hoc follow-up tests of longitudinal epilepsy syndrome group versus healthy control differences in 11 cognitive tests
Omnibus | Post-hoc pa | |||||
---|---|---|---|---|---|---|
Response | pa | Direction | Slope | Base- line |
Year 2 | Year 5 |
Reading | 0.4945 0.495 |
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Spelling | 0.2205 0.221 |
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Arithmetic | 0.0001 <0.001 |
CG>LRE>IGE | 0.5351 0.535 |
<0.0011 | 0.0203 0.020 |
0.008 |
Intelligenceb | 0.0495 0.049 |
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Expressive speech | 0.0536 0.054 |
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Receptive speech | 0.5455 0.546 |
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Problem solving | 0.1454 0.145 |
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Responseb inhibition | <0.0001 <0.001 |
CG>LRE>IGEc | 0.0008 0.001 |
<0.0011 | 0.0019 0.002 |
0.294 |
Attention | 0.0065 0.007 |
CG>LRE=IGE | 0.8975 0.898 |
0.0129 0.013 |
0.0045 0.005 |
0.006 |
Fine motor dexterity | <0.0001 <0.001 |
CG>LRE=IGE | 0.4109 0.411 |
0.0003 <0.001 |
0.0092 0.009 |
<0.010 |
Psychomotorb speed | <0.0001 <0.001 |
CG>LRE>IGE | 0.2076 0.208 |
<.0001 | <.0001 | <0.000 |
Details and multiple comparison adjustments are given in the text.
Critical values (not shown) for omnibus tests were based on ordered Hochberg correction for multiple comparisons across the 11 responses. Post-hoc p values not reported for responses for which omnibus test nominal p values were higher than the Hochberg critical value.
Intelligence, response inhibition and psychomotor speed are presented in Figure 1, and the remaining scales are in the online supplementary information.
For response inhibition, the contrast among groups decreased markedly over time, with LRE similar to the comparison group (CG) at year 5. (See Fig. 1, bottom right panel).