Table 1.
Meta-analysis results for the association between eight melanoma GWAS SNPs and melanoma.
| SNP | Gene | Chromosome / Risk allele | n | # Studies | OR | 95% CI | P-value | Study P-heterogeneity |
|---|---|---|---|---|---|---|---|---|
| rs258322 | CDK10 | 16 / A | 22,082 | 5 | 1.55 | (1.41 - 1.70) | 8.54E-19 | 0.62 |
| rs4785763 | AFG3L1P (near MC1R) | 16 / A | 21,993 | 5 | 1.31 | (1.22 - 1.40) | 1.01E-14 | 0.73 |
| rs16891982 | SLC45A2 (MATP) | 5 / G | 15,949 | 3 | 3.11 | (2.31 - 4.18) | 7.39E-14 | 0.43 |
| rs1393350 | TYR | 11 / A | 22,009 | 5 | 1.25 | (1.17 - 1.35) | 6.21E-10 | 0.80 |
| rs4636294 | MTAP (near CDKN2A) | 9 / A | 22,053 | 5 | 1.18 | (1.11 - 1.27) | 5.51E-07 | 0.18 |
| rs7023329 | MTAP (near CDKN2A) | 9 / A | 22,114 | 5 | 1.17 | (1.10 - 1.25) | 1.93E-06 | 0.36 |
| rs910873 | PIGU (near ASIP) | 20 / A | 15,937 | 3 | 1.31 | (1.15 - 1.48) | 2.46E-05 | 1.00 |
| rs2284063 | PLA2G6 | 22 / G | 22,087 | 5 | 1.09 | (1.01 - 1.16) | 0.019 | 0.27 |
Bold p-values are statistically significant for replication at a Bonferroni-corrected threshold of 0.05/8=0.006. SNPs rs16891982 and rs910873 were not available in HPFS or NHS. SNPs are ordered by p-value.