Table 2. Frequency of NPI symptoms.
| NPI variable | Pooled sample N=6097 | MCI N=3456 | Mild AD N=2641 | Mild AD vs. MCI p-value | Amnestic MCI N=2837 | Nonamnestic MCI N=619 | Amnestic vs. nonamnestic MCI p=value |
|---|---|---|---|---|---|---|---|
| Delusions | 428 (7%) | 122 (4%) | 306 (12%) | <.0001 | 97 (3%) | 25 (4%) | 0.5 |
| Hallucinations | 117 (2%) | 34 (1%) | 83 (3%) | <.0001 | 27 (1%) | 7 (1%) | 0.7 |
| Depression | 1116 (18%) | 669 (19%) | 447 (17%) | .015 | 553 (20%) | 116 (19%) | 0.7 |
| Apathy | 1624 (27%) | 627 (18%) | 997 (38%) | <.0001 | 520 (18%) | 107 (17%) | 0.5 |
| Anxiety | 1579 (25%) | 705 (20%) | 825 (31%) | <.0001 | 585 (21%) | 120 (19%) | 0.5 |
| Irritability | 1891 (31%) | 908 (26%) | 983 (37%) | <.0001 | 749 (26%) | 159 (26%) | 0.7 |
| Agitation | 1340 (22%) | 562 (16%) | 778 (30%) | <.0001 | 479 (17%) | 83 (13%) | 0.034 |
| Disinhibition | 707 (12%) | 274 (8%) | 433 (16%) | <.0001 | 218 (8%) | 56 (9%) | 0.3 |
| Elation | 148 (2%) | 56 (2%) | 92 (3%) | <.0001 | 52 (2%) | 4 (1%) | 0.034 |
| Aberrant motor behavior | 482 (8%) | 149 (4%) | 333 (13%) | <.0001 | 117 (4%) | 32 (5%) | 0.2 |